WP1 – Associating native gut microbiome signatures with CC

Objectives: 1/ Identify cachexia-associated gut microbiome signatures common to and/or specific to different cancer types. • 2/ Explore the role of the gut microbiome as a mediator in cachexia progression in CRC patients. • 3/ Describe the gut microbiome dynamics and muscle and VAT wasting in LC patients. • 4/ Find associations between gut microbiome and specific body and tissue features (e.g., immune, hormonal) in CC of 4 different cancer types. • 5/ Identify potentially beneficial bacterial consortia and microbial metabolites • 6/ Develop ML models for microbiome-based diagnosis and prognosis of CC.